Study of 138 #AOSD (Stills) pts – 19% were obese BMI>30. Obese with AOSD have same clinical features as others, but may have higher ferritin & CRP (correl w/ BMI) and more likely to have chronic disease course and bDMARD failure. https://t.co/16wKVGTWnN https://t.co/daR9hZpA89

Pyoderma gangrenosum review in BMJ – an ulcerative neutrophilic autoinflammatory disorder; often associated with underlying systemic disease – IBD, seronegative RA, hematological malignancies or monoclonal gammopathies, etc. https://t.co/AGorrWNfAQ https://t.co/hawksCEHRA

Prospective cohort study of 41 Stills Dz pts w/ ILD – 85% had 1+MAS & 41% with adverse reactions to a biologic. 93% were alive w/ median F/U 3 years, but 37% progressed to chronic lung dz (O2, or vent) & 84% were HLA-DRB1*15 https://t.co/fo44fgKh8m https://t.co/xa9g4Slr1H

Japanese study of 98 pts w/ VEXAS syndrome [81M: 8F; age 69.3 yrs) found 45% (40pts) with pathogenic UBA1 variants. VEXAS Dx Score based on: age >50 yrs, skin lesions, lung Sxs, chondritis, macrocytic anaemia (AUC=0.908) https://t.co/W2bSmuGf6l https://t.co/EwHuRk4GCr