IL-1 and IL-6 Inhibition Preferred in Systemic JIA
Since 2000, the German Biologics register (BiKeR) has prospectively enrolled children with juvenile idiopathic…
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Q Fever – The Intersection of Rheum and ID
Today in clinic, I saw a patient with longstanding seropositive, erosive rheumatoid arthritis who…
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Biologic Use in Adult-Onset Still's Disease
Adult-onset Still’s disease (AOSD) is the adult continum of systemic-onset juvenile idiopathic arthritis (SoJIA).…
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“The Big Sick” Movie Review
It’s Monday morning and my first patient is a newly diagnosed rheumatoid. This is his…
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NLRP3 Activation in Still's Disease
Adult-onset Still disease (AOSD) is usually regarded as an autoinflammatory disease, largely because of…
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New Criteria for the Cryopyrinopathies (CAPS)
The diagnosis of periodic fevers is unified by undiagnosed but recurrent fever. Unfortunately the…
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NIH Discovers Otulipenia – New Infantile Autoinflammatory Disorder
Researchers at the National Institutes of Health, led by Dr. Dan Kastner, have led…
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Canakinumab Yields Genetic and Disease Modifying Effects in TRAPS Patients
Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory disease resulting…
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Epigenetic Changes to Inflammasome Found in Autoinflammatory Syndromes
Autoinflammatory syndromes manifest as periodic fevers in children, and are the result of monogenic,…
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New Classification Criteria for Macrophage Activation Syndrome
Systemic juvenile idiopathic arthritis (SoJIA) is one of the most common underlying etiologies to…
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